| Autor: |
Pisarev, D., Sancovich, H., Sancovich, A. |
| Zdroj: |
Journal of Endocrinological Investigation; December 1989, Vol. 12 Issue: 11 p767-772, 6p |
| Abstrakt: |
The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4and L-125-I-T3, kinetics of radiolabeled hormones metabolism were calculated. The T4metabolic clearance (MCI) as well as the distribution space, were increased by 6 fold. Decreased serum T4levels result from an increase both in deiodinative and fecal disposal in HCB-treated rats. 125I-T3metabolism was slightly affected. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroid function, as measured by augmented TSH serum levels and 125I-thyroidal uptake. Serum binding of T4was not affected. |
| Databáze: |
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| Externí odkaz: |
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