The growth hormone responses to L-dopa and TRH in acromegaly

Autor: Jialal, I., Naidoo, C., Nathoo, B., Rajput, M., Joubert, S.
Zdroj: Journal of Endocrinological Investigation; June 1984, Vol. 7 Issue: 3 p235-237, 3p
Abstrakt: The GH responses to TRH and L-dopa were investigated in 14 Indian and African patients with untreated acromegaly. A positive response to L-dopa (> 50% change from basal) was obtained in 6 of the 14 patients tested while a positive response to TRH (> 100% change from basal) was found in 5 of 12 patients tested. While 9 patients responded to at least one agent, only 2 had a positive response to both agents. Positive responders appeared to be hyper-prolactinemic and have evidence of abnormal glucose tolerance as compared to nonresponders.
Databáze: Supplemental Index