| Autor: |
Imai, Hirokazu, Oyama, Yuhta, Miura, Akira B., Endoh, Masayuki, Sakai, Hideto |
| Zdroj: |
American Journal of Kidney Diseases; September 2000, Vol. 36 Issue: 3 p474-480, 7p |
| Abstrakt: |
To clarify the incidence and characteristics of hematopoietic cell transplantation (HCT)-related nephropathy (HCT-N) in Japan, we sent questionnaire letters to 188 hematologic divisions of 91 hospitals and analyzed the responses. Of 2,136 Japanese hematopoietic cell transplant recipients, 51 patients (2.4%) had HCT-N. The early-onset (≤30 days after HCT), middle-onset (31 to 120 days after HCT), and late-onset (180 days after HCT) groups included 20, 16, and 15 patients, respectively. The early-onset group mainly consisted of patients with acute renal failure (ARF) and hemolytic uremic syndrome and/or thrombotic thrombocytopenic purpura. ARF was the dominant type in the middle-onset group. The main phenotype of the late-onset group was nephrotic syndrome, which correlated with chronic graft-versus-host disease (P= 0.008). The total amounts of irradiation for patients with chronic renal failure and urinary abnormality were significantly greater than those for patients with ARF (P= 0.004). The survival rate of the early-onset and middle-onset groups was 47.2%, whereas 87% of patients in the late-onset group survived (P= 0.002). HCT-N is expected to become a serious and important problem in Japan because of the increasing number of HCTs from unrelated donors. |
| Databáze: |
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