| Autor: |
Massara, Ferdinanda, Camanni, F., Vergano, V., Belforte, L., Molinatti, G. |
| Zdroj: |
Journal of Endocrinological Investigation; January 1978, Vol. 1 Issue: 1 p25-30, 6p |
| Abstrakt: |
The effect of dopamine on thyrotropin (TSH) and prolactin (PRL) levels was studied in 5 normal subjects, 7 women with galactorrhea, 9 acromegalics and 4 patients with primary hypothyroidism. Dopamine infused at the rate of 280 μg/min produced significant decrease in plasma TSH and PRL levels in all four groups, though a lower fall in TSH was noted in acromegalics. A similar reduction in PRL was also noted after 28 μg/min dopamine. Phentolamine infusion (0.5 mg/min) had no effect on PRL response to dopamine. These results indicate that a dopaminergic stimulation led to an inhibition of TSH and PRL secretion. Since the high polarity of dopamine impedes its passage through the blood-brain barrier, its site of action should be outside this barrier, probably in the pituitary. |
| Databáze: |
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| Externí odkaz: |
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