| Autor: |
Bock, Jonathan M., Johnston, Nikki, Toohill, Robert J., Koszewski, Ian J., Samuels, Tina L., Blumin, Joel H. |
| Zdroj: |
Perspectives on Voice and Voice Disorders; November 2011, Vol. 21 Issue: 3 p118-123, 6p |
| Abstrakt: |
Extraesophageal reflux (EER) has been implicated in a variety of different otorhinolaryngologic disorders including otitis media, chronic sinusitis, globus pharyngeus, laryngeal neoplasia, and many benign laryngeal disorders. New technologies such as multichannel intraluminal impedance studies have revolutionized our ability to detect the prevalence of EER, and the role of biomarker detection in diagnosing ongoing EER is evolving. Gastric refluxate contains not only hydrochloric acid, but also bile salts and digestive enzymes such as pepsin. Analysis of pepsin levels in both tissues and secretions is emerging as a useful adjunct in the diagnosis of EER and work to evaluate the role of pepsin in the promotion of laryngeal inflammation and neoplasia is ongoing. This review discusses the recent literature regarding the diagnosis and treatment of EER, and describes the controversies that can perhaps be further elucidated by ongoing clinical and translational research. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
