Antibiotic Resistance Genes in the Bacteriophage DNA Fraction of Human Fecal Samples

Autor: Quirós, Pablo, Colomer-Lluch, Marta, Martínez-Castillo, Alexandre, Miró, Elisenda, Argente, Marc, Jofre, Juan, Navarro, Ferran, Muniesa, Maite
Zdroj: Antimicrobial Agents and Chemotherapy; November 2013, Vol. 58 Issue: 1 p606-609, 4p
Abstrakt: ABSTRACTA group of antibiotic resistance genes (ARGs) (blaTEM, blaCTX-M-1, mecA, armA, qnrA, and qnrS) were analyzed by real-time quantitative PCR (qPCR) in bacteriophage DNA isolated from feces from 80 healthy humans. Seventy-seven percent of the samples were positive in phage DNA for one or more ARGs. blaTEM, qnrA, and, blaCTX-M-1were the most abundant, and armA, qnrS, and mecAwere less prevalent. Free bacteriophages carrying ARGs may contribute to the mobilization of ARGs in intra- and extraintestinal environments.
Databáze: Supplemental Index