| Autor: |
Hayatsu, Eizo, Kawakubo, Yasuaki, Yayoshi, Masumi, Araake, Minako, Yoshioka, Morimasa, Nishiyama, Yasukazu |
| Zdroj: |
Microbiology and Immunology; July 1980, Vol. 24 Issue: 7 p585-593, 9p |
| Abstrakt: |
Golden Syrian hamsters adoptively immunized with hyperimmune Mycoplasma pneumoniaerabbit antiserum, immunoglobulin (Ig) M‐rich (IgM) fraction, IgG‐rich (IgG) fraction, antiserum absorbed with either killed M. pneumoniaeor killed Staphylococcus aureusorganisms, or antiserum treated with 2‐mercaptoethanol (2‐ME) were examined for resistance against aerosol infection with virulent M. pneumoniae. Significant resistance to the establishment of infection in the respiratory tract was shown in hamsters pretreated with the untreated antiserum, IgG fraction or 2‐ME‐treated antiserum, whereas animals pretreated with the IgM fraction and the antisera absorbed with M. pneumoniaeor S. aureusorganisms were not significantly resistant. Histopathologically, lung lesions were markedly suppressed in animals with high resistance, but were typically pneumonic in animals with low or no resistance. The efficacy of adoptively administered serum preparations was closely related to their antibody titers. The results indicate that humoral antibody plays an important role in protection against experimental M. pneumoniaepneumonia in hamsters, although the participation of the cell‐mediated immune response was not determined. |
| Databáze: |
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