Immune Response to Toxoplasma gondii

Autor: Yano, Akihiko, Yui, Katsuyuki, Yamamoto, Masuji, Aosai, Fumie, Furuta, Seiichi, Kojima, Soumei
Zdroj: Microbiology and Immunology; May 1983, Vol. 27 Issue: 5 p455-463, 9p
Abstrakt: Peripheral blood leukocytes (PBL) from patients with toxoplasmosis were shown to be highly responsive to in vitrostimulation with Toxoplasma gondiiextract as measured by incorporation of [3H]methylated thymidine. Analysis of Toxoplasma‐specific proliferative cells in PBL by using monoclonal antibodies specific for human T cell subsets revealed that the Toxoplasma‐specific proliferation response of PBL from the patients was mediated by Leu 1, Leu 3a positive cells, that is, helper/inducer T cells. Tests for the Toxoplasma‐specific proliferation response may provide a readily available method for the diagnosis of congenital toxoplasmosis, especially during the newborn period.
Databáze: Supplemental Index