| Autor: |
Saito, Shinji, Onozuka, Kazuyasu, Shinomiya, Hiroto, Nakano, Masayasu |
| Zdroj: |
Microbiology and Immunology; April 1991, Vol. 35 Issue: 4 p325-329, 5p |
| Abstrakt: |
Sensitivity of bacteria to NO2‐/NO and to L‐arginine‐dependent system in murine macrophages was tested. The growth of all bacteria tested, Salmonella typhimurium, Pseudomonas aeruginosaand Staphylococcus epidermidis, was significantly inhibited by NaNO2at the concentration of 5 to 10 mM. However, L‐arginine‐dependent effector mechanism of LPS‐activated murine macrophages was ineffective in killing these bacteria. It seems that the concentration of NO2‐/NO in phagolysosome in the activated macrophages is insufficient to kill the bacteria in situ.We concluded that L‐arginine‐dependent effector mechanism can hardly work on bacteria killing in activated macrophages. |
| Databáze: |
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