| Autor: |
Ehara, Masahiko, Ichinose, Yoshio, Iwami, Mamoru, Utsunomiya, Akiyoshi, Shimodori, Shoichi, Kangethe, Stanley K., Neves, Bianca C., Supawat, Krongkaew, Nakamura, Satoshi |
| Zdroj: |
Microbiology and Immunology; September 1993, Vol. 37 Issue: 9 p679-688, 10p |
| Abstrakt: |
Parenteral immunization with either formalin‐fixed whole cells of the fimbriate Bgd17 strain or purified fimbriae protected against Vibrio choleraeO1 infection in rabbits, independent of biotype and serotype. Parenteral immunization of adult rabbits with purified fimbriae prior to V. choleraeO1 challenge resulted in a reduction of 2 to 3 orders of magnitude in the number of bacteria recovered from the small intestines of immunized rabbits in comparison to non‐immunized controls. IgG and IgA antibodies against fimbrillin of V. choleraeO1 were detected in the convalescent sera of patients with cholera; however, little fimbrial antigen was detected in the commercially available cholera vaccines when examined by polyclonal and monoclonal antibodies against fimbriae. These data suggest that fimbrial hemagglutinin is a major adhesin of V. choleraeO1 and that parenteral immunization with fimbriae generates a specific immune response in the gut that may serve as one means of mitigating subsequent V. choleraeO1 gut infection. |
| Databáze: |
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