The neuroprotective effects of MK-801 on the induction of microgyria by freezing injury to the newborn rat neocortex

Autor: Rosen, G.D., Sigel, E.A., Sherman, G.F., Galaburda, A.M.
Zdroj: Neuroscience; 1995, Vol. 69 Issue: 1 p107-114, 8p
Abstrakt: Four-layered microgyria is associated with many developmental disorders, including mental retardation, epilepsy, and developmental dyslexia. Freezing lesions to the newborn rodent neocortex result in the formation of four-layered microgyria. Previous research had suggested this type of injury acts as an hypoxic/ischemic event to the developing cortical plate. The current study examines the effectiveness of the non-competitive N-methyl-d-aspartate receptor antagonist dizocilpine (MK-801) in protecting against freezing injury to the newborn rat cortical plate.
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