Magnesium ions reduce motoneuron death following nerve injury or exposure to N-methyl-d-aspartate in the developing rat

Autor: Greensmith, L., Mooney, E.C., Waters, H.J., Houlihan-Burne, D.G., Lowrie, M.B.
Zdroj: Neuroscience; October 1995, Vol. 68 Issue: 3 p807-812, 6p
Abstrakt: Developing motoneurons can be induced to die by target deprivation and there is evidence that this cell death involves the excitotoxic effects of N-methyl-d-aspartate. Treatment with dizocilpine maleate, an antagonist of this receptor, has been shown to rescue a proportion of those motoneurons destined to die following nerve injury at birth. However, this is a relatively toxic compound. In this study we examined whether systemic treatment with magnesium sulphate, a non-competitive antagonist of the N-methyl-d-aspartate receptor which is better tolerated than dizocilpine maleate, could prevent motoneuron death.
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