| Autor: |
Elkabes, S., Schaar, D.G., Dreyfus, C.F., Black, I.B. |
| Zdroj: |
Neuroscience; 1995, Vol. 66 Issue: 4 p879-889, 11p |
| Abstrakt: |
Extensive evidence indicates that the survival and development of neurons is dependent on neurotrophins. However, the factors potentially required for glial development and function, and the sites of synthesis, are not well defined. To investigate the potential role of neurotrophins in glial developmentin vivo, we studied the trk family of receptors and their cognate neurotrophins in the postnatal rat optic nerve using reverse transcription-polymerase chain reaction. Our results indicate that trk A, B and C messenger RNAs are expressed throughout development, and in adulthood. Both trk B and trk C expression detectable during development. However, trk C expression decreased most markedly, reaching barely detectable levels by day 90. These findings suggest that neurotrophins can affect both immature and mature glial function and that their actions may be regulated through the modulation of putative receptors. |
| Databáze: |
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