| Autor: |
Funada, Ulala, Wada, Masahiro, Kawata, Tetsunori, Mori, Kazumi, Tamai, Hiroko, Kawanishi, Tomiko, Kunou, Akiko, Tanaka, Nobuo, Tadokoro, Tadahiro, Maekawa, Akio |
| Zdroj: |
International Journal for Vitamin and Nutrition Research; July 2000, Vol. 70 Issue: 4 p167-171, 5p |
| Abstrakt: |
To clarify the role of vitamin B12in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8–/CD4–CD8+ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4+CD8–/CD4–CD8+ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12plays a role in maintaining the immune function in rats. |
| Databáze: |
Supplemental Index |
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