| Autor: |
Clatworthy, A.L., Noel, F., Grose, E., Cui, M., Tofilon, P.J. |
| Zdroj: |
Neuroscience Letters; June 1999, Vol. 268 Issue: 1 p45-48, 4p |
| Abstrakt: |
It is clear that ionizing radiation can alter neuronal function. Recently it has been suggested that radiation can directly influence neurons and/or the neuronal microenvironment. We have developed a simple in vitro model system utilizing the marine mollusc Aplysia californicato test this hypothesis. We show that ionizing radiation at doses of 5, 10 or 15 Gy produces complex effects on the electrophysiological properties of a population of Aplysianociceptive sensory neurons at 24 and 48 h post irradiation. These results add support to the notion that ionizing radiation can directly influence neurons and/or the neuronal microenvironment. Furthermore, they demonstrate that Aplysiamay be used as a useful model system to study radiation-induced neuronal plasticity. |
| Databáze: |
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