Nicotinamide as a precursor for NAD^+ prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide

Autor: Klaidman, L.K., Mukherjee, S.K., Hutchin, T.P., Adams, J.D.
Zdroj: Neuroscience Letters; March 1996, Vol. 206 Issue: 1 p5-8, 4p
Abstrakt: The vitamin nicotinamide can protect against oxidative stress-induced apoptosis in the brain when used as a precursor for nicotinamide adenine dinucleotide (NAD^+). The intracerebroventricular administration of tertiary-butylhydroperoxide (t-buOOH) to mice was used to simulate physiologic oxidative stress and apoptosis which may occur in some neurodegenerative conditions. t-buOOH produced characteristic apoptotic nuclear degeneration in neurons with extensive fragmentation of DNA. In this report we show that the elevation of NAD^+ levels can be increased by 50% in the brain. This may prevent the critical depletion of NAD^+ by poly(ADP-ribose)polymerase (PARP) and provide additional substrate during the repair of DNA. Nicotinamide may be of particular interest in the treatment of neurodegeneration.
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