| Autor: |
Kempster, S., Phillips, W.A., Baindur-Hudson, S., Thomas, R.J.S., Dow, C., Rockman, S.P. |
| Zdroj: |
Cancer Letters; March 2000, Vol. 150 Issue: 1 p57-62, 6p |
| Abstrakt: |
Methylation of the p16gene was studied in 16 oesophageal tumours. Five (31%) of the tumours were found to be methylated in exon 1 and eight (50%) were methylated in exon 2. The loss of p16 protein correlated with methylation of exon 1 (P=0.005). However, methylation of exon 2, but not exon 1, was found to be associated with late stage tumours (P=0.01). We conclude that the methylation of exon 2 of p16may have effects on the progression of oesophageal tumours that are independent of the expression of the p16 protein. |
| Databáze: |
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| Externí odkaz: |
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