| Autor: |
Ramser, Elisa M., Gan, Kathlyn J., Decker, Helena, Fan, Emily Y., Suzuki, Matthew M., Ferreira, Sergio T., Silverman, Michael A. |
| Zdroj: |
Molecular Biology of the Cell; August 2013, Vol. 24 Issue: 16 p2494-2505, 12p |
| Abstrakt: |
The role of tau in axonal transport disruption during early-stage Alzheimer disease is controversial. The amyloid-β oligomers markedly impair BDNF transport in primary wild-type and tau-knockout neurons. This occurs by nonexcitotoxic activation of calcineurin, and inhibition of calcineurin rescues transport defects independent of tau. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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