Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

Autor: Woo Jung, Yon, Lee, Hwanbum, Yeon Kim, Jae, Jin Koo, Eun, Sang Oh, Keun, Hong Yuk, Soon
Zdroj: Current Medicinal Chemistry; September 2013, Vol. 20 Issue: 28 p3488-3499, 12p
Abstrakt: Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
Databáze: Supplemental Index
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