| Autor: |
Zhang, Rui Fang, Zhang, Rui Rui, Lu, Yu Jing, Du, Zhi Yun, Fu, Cheng Jie, Tang, Zhi Kai, Fang, Yan Xiong, Zhang, Kun |
| Zdroj: |
Advanced Materials Research; June 2013, Vol. 711 Issue: 1 p73-78, 6p |
| Abstrakt: |
Several derivatives of 5-methyl-benzofuro [3,2-quinoline (O-isostere of cryptolepine) were synthesized. Spectrometric experiments and molecular modeling indicated that these derivatives interacted with duplex DNA by intercalation binding mode. The derivatives with aniline substituent exhibited superior DNA binding affinity to that of lead compound 5-methyl-benzofuro [3,2-quinoline. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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