| Autor: |
Holder, Claude L., Slitonen, Paul H., Slikker, William, Branscomb, Carolyn J., Korfmacher, Walter A., Thompson, Harold C., Cerniglia, Carl E., Gosnell, Aubrey B., Lay, Jackson O. |
| Zdroj: |
Journal of Analytical Toxicology; July 1990, Vol. 14 Issue: 4 p247-247, 1p |
| Abstrakt: |
Elimination and metabolic profiles of the glucuronide products of doxylamine and its N-demethylated metabolites were determined after the oral administration of (14C)-doxylamine succinate (13.3 and 133 mg/kg doses) to male and female Fischer 344 rats. The cumulative urinary and fecal eliminations of these conjugated doxylamine metabolites at the 13.3 mg/kg dose were 44.4 ± 4.2% and 47.3 ± 8.1% of the total recovered dose for male and female rats, respectively. The cumulative urinary and fecal eliminations of conjugated doxylamine metabolites at the 133 mg/kg dose were 55.2 ± 2.6% and 47.9 ± 2.5% of the total recovered dose for male and female rats, respectively. The conjugated doxylamine metabolites that were isolated, quantitated, and identified are doxylamine O-glucuronide, N-desmethyldoxylamine O-glucuronide, and N,N-didesmethyldoxylamine O-glucuronide. |
| Databáze: |
Supplemental Index |
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