| Abstrakt: |
Objective:We previously reported in an open-label pilot trial that a 24-ingredient multivitamin formula favorably influenced homocysteine concentration and LDL-C oxidation indices following 24 weeks of supplementation. Our current aim was to more thoroughly examine this same formula in a randomized, placebo-controlled, clinical study.Methods:We examined 182 participants for selected plasma vitamin concentrations and clinically relevant variables including homocysteine, lipids and LDL-C oxidation indices at baseline and six months.Results:We found no significant differences between groups for any parameter at baseline. Following six months of vitamin supplementation, we observed elevations in plasma concentrations of vitamin B6 (as pyridoxal 5′-phosphate; PLP), vitamin B12, folate, vitamin C, vitamin E and β-carotene (p< 0.0001), all of which were significantly greater than respective placebo group changes (p< 0.0001). Homocysteine decreased in the treatment (8.38 ± 2.9 vs.6.93 ± 2.5 μmol/L; p< 0.0001) and placebo group (8.17 ± 3.0 vs.7.42 ± 2.2 μmol/L; p< 0.0001) from baseline to six months, respectively, with reductions in the treatment group being greater than placebo (p< 0.008). LDL-C oxidation indices were also improved as LDL-C oxidation rate was decreased (−0.39 μmol/min/g protein; p< 0.0003) and LDL-C lag time increased (11.3 min; p< 0.003) in supplemented participants. Further analysis also showed that LDL-C oxidation rate was lower (p< 0.0007) and LDL-C lag time longer (p< 0.0001) for the vitamin group than placebo treatment after six months.Conclusion:We conclude that a multi-ingredient vitamin formula with antioxidant properties has measurable effects on homocysteine and LDL-C oxidation indices. |
