| Autor: |
Zhao, Yan-Fang, Liu, Zi-Jian, Zhai, Xin, Ge, Dan-Dan, Huang, Qiang, Gong, Ping |
| Zdroj: |
Chinese Chemical Letters; May 2013, Vol. 24 Issue: 5 p386-388, 3p |
| Abstrakt: |
A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl)pyrimidine-4-yl]piperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Among them, compound 2pdemonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC50values of 0.016, 0.63, 0.001μmol/L, respectively. |
| Databáze: |
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