| Autor: |
Abrahamsson, Bertil, Lücker, Peter, Olofsson, Bertil, Regårdh, Carl‐Gunnar, Sandberg, Anders, Wieselgren, Ingrid, Bergstrand, Robert |
| Zdroj: |
Journal of Clinical Pharmacology; February 1990, Vol. 30 Issue: Supplement 2 pS46-S54, 9p |
| Abstrakt: |
Four studies using different daily doses (100 mg, 200 mg, 300 mg and 400 mg) have examined the bioequivalence of the once daily formulation metoprolol CR/ZOK and conventional metoprolol tablets (CT). These studies showed metoprolol CR/ZOK to have a similar beta1‐blocking activity to metoprolol CT but that the bioavailability of the new formulation was lower. This paper presents the analysis of data from all four studies, looking at the relationship between plasma concentrations and beta1‐blockade measured as reduction of exercise induced tachycardia. |
| Databáze: |
Supplemental Index |
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