| Autor: |
Shukla, Rakesh, Srimal, Rikhab Chand, Prasad, Chandan |
| Zdroj: |
Peptides; January 1997, Vol. 18 Issue: 5 p689-693, 5p |
| Abstrakt: |
Shukla, R., R. C. Srimal and C. Prasad. Cyclo(His-Pro) modulation of body temperature at hot ambient temperature in the desert rat (Mastomys natalensis). Peptides 18(5) 689–693, 1997.—Cyclo(His-Pro) (CHP) has been shown to facilitate cold-induced hypothermia in the desert rat Mastomys natalensis.In the present study, we examined the role of endogenous CHP in hyperthermia induced by hot ambient temperature (40°C) in the above rodent species. The results of these studies show that housing rodents at 40°C resulted in a altered distribution of CHP in the brain, with a rise in hypothalamic content accompanied by an increase in rectal temperature. While administration of exogenous CHP decreased hyperthermia, immunoneutralization of endogenous CHP increased hyperthermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation. |
| Databáze: |
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