| Autor: |
OVERTON, ROSE M, VESELY, DAVID L |
| Zdroj: |
Peptides; January 1996, Vol. 17 Issue: 7 p1155-1162, 8p |
| Abstrakt: |
OVERTON, R.M. AND D.L. VESELY. Processing of long-acting natriuretic peptide and vessel dilator in human plasma and serum. PEPTIDES 17(7) 1155–1162, 1996.—High performance-gel permeation chromotography (HP-GPC) evaluation of human plasma and serum incubated at 37°C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p< 0.001). Vessel dilator's HP-GPC peak did not decrease until after 8 h of incubation. These findings help explain the prolonged half-lives and 6–24 higher plasma concentrations of vessel dilator and LANP compared to atrial natriuretic factor and kaliuretic peptide, which are completely degraded in plasma within 2 h. Published by Elsevier Science Inc. |
| Databáze: |
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