| Autor: |
Lauria, Antonino, Abbate, Ilenia, Gentile, Carla, Angileri, Francesca, Martorana, Annamaria, Almerico, Anna Maria |
| Zdroj: |
Journal of Medicinal Chemistry; 20240101, Issue: Preprints |
| Abstrakt: |
The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50confirmed its specific influence on the cellular pathways involving Hsp90. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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