| Autor: |
Harun, Nurhana Ilmira, Md Ali, Ruslinda, Marwan Ali, Abd Malik, Yahya, Muhd Zu Azhan |
| Zdroj: |
Advanced Materials Research; March 2013, Vol. 667 Issue: 1 p155-159, 5p |
| Abstrakt: |
Carbon nanotubes (CNTs) were reported to cause severe toxicity in in vivo and in vitro studies. On the other hand, CNTs has the potential as a mechanism for drug delivery across the blood brain barrier due to its nano-sized dimensions. The present preliminary study examined the cytotoxic effect of CNTs in serum-free and serum-containing EMEM medium on neuroblastoma cells growth. The MTS assay showed that CNTs did not cause any cytotoxicity at concentrations below 0.1 mg/mL at 24 and 48 h incubation in serum-containing EMEM medium. This finding suggested that below 0.1 mg/mL, CNTs can be used as a mechanism for drug delivery for the treatment of neuronal cancer. However, CNTs showed slighty toxic towards neuroblastoma cells at concentration 0.1 mg/ml at 48h incubation in serum-free EMEM medium. This finding indicates that the present of serum play a role for toxicity effect of CNTs in cells. |
| Databáze: |
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