| Autor: |
Tanaka, Yukinori, Nanamiya, Hideaki, Yano, Koichi, Kakugawa, Koji, Kawamura, Fujio, Ochi, Kozo |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; January 2013, Vol. 57 Issue: 4 p1948-1951, 4p |
| Abstrakt: |
ABSTRACTBacillus subtiliscontains 10 rRNA (rrn) operons. We found that rRNA operon-engineered B. subtilisstrain RIK543, with only the rrnOoperon, is specifically hypersensitive to RNA polymerase inhibitors such as rifamycin SV and rifampin (80-fold and 20-fold, respectively). In pilot screening experiments, we found actinomycete isolates successfully at an incidence of 1.9% (18/945) that produced antibacterials that were detectable only with RIK543 as the test organism. Strain RIK543 may be a feasible test organism for the discovery of novel RNA polymerase inhibitors. |
| Databáze: |
Supplemental Index |
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