| Autor: |
Lake, Sarah L., Damato, Bertil E., Kalirai, Helen, Dodson, Andrew R., Taktak, Azzam F.G., Lloyd, Bryony H., Coupland, Sarah E. |
| Zdroj: |
American Journal of Pathology; March 2013, Vol. 182 Issue: 3 p678-687, 10p |
| Abstrakt: |
Metastatic death from uveal melanoma occurs almost exclusively with tumors showing monosomy of chromosome 3. However, approximately 5% of patients with a disomy 3 uveal melanoma develop metastases, and a further 5% of monosomy 3 uveal melanoma patients exhibit disease-free survival for >5 years. In the present study, whole-genome microarrays were used to interrogate four clinically well-defined subgroups of uveal melanoma: i) disomy 3 uveal melanoma with long-term survival; ii) metastasizing monosomy 3 uveal melanoma; iii) metastasizing disomy 3 uveal melanoma; and iv) monosomy 3 uveal melanoma with long-term survival. Cox regression and Kaplan–Meier survival analysis identified that amplification of the CNKSR3gene (log-rank, P= 0.022) with an associated increase in its protein expression (log-rank, P= 0.011) correlated with longer patient survival. Although little is known about CNKSR3, the correlation of protein expression with increased survival suggests a biological function in uveal melanoma, possibly working to limit metastatic progression of monosomy 3 uveal melanoma cells. |
| Databáze: |
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