| Autor: |
Sofola, O A, Odusote, K A |
| Zdroj: |
The Journal of Pharmacology and Experimental Therapeutics; January 1976, Vol. 196 Issue: 1 p29-34, 6p |
| Abstrakt: |
The cardiovascular effects of intravenously administered strychnine were studied in anesthetized and paralyzed dogs. Administration of strychnine in cumulative doses of up to 0.1 to 0.2 mg/kg caused significant pressor, as well as positive inotropic and chronotropic, effects on the heart which were abolished by adrenergic blocking agents. The cardiovascular responses possibly were elicited by a central mechanism in contrast to the peripheral inhibitory action of strychnine on the sympathetic system. Diazepam caused a marked attenuation of the pressor response with only slight changes on the heart. A combination of diazepam and propranolol would appear to be a useful therapy in cases of strychnine poisoning showing marked cardiovascular excitation. |
| Databáze: |
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| Externí odkaz: |
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