| Autor: |
Wurzburger, R J, Miller, R L, Boxenbaum, H G, Spector, S |
| Zdroj: |
The Journal of Pharmacology and Experimental Therapeutics; November 1977, Vol. 203 Issue: 2 p435-441, 7p |
| Abstrakt: |
Antibodies, against atropine, were produced in rabbits immunized with atropine conjugated to bovine serum albumin. The antisera possessed a high binding affinity and were quite specific. The sensitivity of the method allowed detection of 6.25 ng of atropine per ml of plasma in a 10-microliter specimen. The method does not require an extraction procedure and can be performed using very small volumes of plasma. Plasma concentration-time profiles were determined by this method in dogs after rapid i.v. administration of atropine. Atropine declined from plasma in a biexponential fashion, exhibiting a terminal half-life of approximately 2.1 hours. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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