| Autor: |
Sakurai, T, Bing, O H, Huber, G, Abelmann, W H |
| Zdroj: |
The Journal of Pharmacology and Experimental Therapeutics; July 1980, Vol. 214 Issue: 1 p219-222, 4p |
| Abstrakt: |
The acute effects of acetaldehyde upon the performance of isolated rat papillary muscle were studied. At high concentrations (50 and 100 mg/100 ml), acetaldehyde demonstrated a negative inotropic effect and abbreviated relaxation time. Pretreatment with either propranolol or reserpine unmasked a direct negative inotropic effect of acetaldehyde at concentrations as low as 5 mg/100 ml. The shortening of relaxation was also blocked by propranolol and reserpine. These findings are compatible with both a direct myocardial depressant effect and an indirect beta-stimulatory effect of acetaldehyde. In the range of concentrations encountered clinically, however, acetaldehyde is not likely to have a significant acute effect upon cardiac muscle performance. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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