| Autor: |
Schnackenberg, Christine, Tucker, Brett, Pigg, Kristi, Granger, Joey |
| Zdroj: |
American Journal of Hypertension; February 1997, Vol. 10 Issue: 2 p226-226, 1p |
| Abstrakt: |
The purpose of this study was to determine long-term role of nitric oxide in modulating the chronic renal and arterial pressure responses to angiotensin II (AII). In normal dogs, intrarenal AII infusion (1.0 ng/kg/min) decreased renal plasma flow (RPF) by 31% and glomerular filtration rate (GFR) by 17% and increased mean arterial pressure (MAP) by 22%. In dogs with chronic intrarenal NO synthesis blockade with N?-nitro-L-arginine methyl ester (3 µg/kg/min), AII decreased RPF by 25% and GFR by 19%, and increased MAP by 7%. These data indicate that chronic inhibition of NO synthesis within the kidney attenuated the long-term renal and arterial pressure responses to AII in dogs. © 1997 American Journal of Hypertension, Ltd. Am J Hypertens 1997;10:226–229 |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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