| Autor: |
Hisamatsu, Ken-ichi, Ganbo, Tetsuya, Goto, Rei, Nakazawa, Tsutomu, Murakami, Yoshihiko |
| Zdroj: |
Auris Nasus Larynx; January 1995, Vol. 22 Issue: 3 p165-171, 7p |
| Abstrakt: |
For a quantitative investigation of eosinophil activation in perennial allergic rhinitis, eosinophil cationic protein (ECP) concentrations were measured by a radioimmunoassay in serum, nasal secretions (ECPWN) and in the supernatant of these nasal secretions (ECPsup) obtained from normal subjects and allergic patients. Levels of ECPWNand ECPsupwere higher than that of ECPserum. ECPsupshowed a positive correlation with clinical severity, despite the lack of a significant correlation with eosinophilia in nasal smears. ECPWNand ECPserumshowed no significant correlation with any of these clinical parameters. There was a weak tendency toward an increase in histamine sensitivity of the nasal mucosa of allergic patients with higher ECPsupalthough this was not statistically significant. These results suggest accumulation and activation of eosinophils in the allergic nasal mucosa, and also indicate that ECPsupmay be a clinical parameter of perennial allergic rhinitis. |
| Databáze: |
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