| Abstrakt: |
During the eight years since Werner Schultz of Berlin first gave the name "agranulocytosis" or "agranulocytic angina" to a group of cases that have a severe ulcerative and gangrenous stomatitis and a neutrophil leukopenia with a relative lymphocytosis, many cases have been reported, chiefly by German and American observers. The literature dealing with this peculiar phenomenon has been repeatedly and comprehensively reviewed to date. Many clinicians regard agranulocytosis as a hitherto undescribed disease entity, but numerous writers maintain that the picture described by Schultz is not specific and hold to the view that so-called agranulocytosis simply constitutes a type of leukopenic reaction to an overwhelming infection. Whatever the view, there are features in the reported cases sufficiently striking, uniform and frequent to warrant separate group consideration.Cases are common to the two sexes with an incidence of about 70 per cent in females, and they occur in all age groups, |
