CAPILLARY PERMEABILITY IN ANAPHYLAXIS

Autor: MANWARING, W. H., CHILCOTE, R. C., HOSEPIAN, V. M.
Zdroj: JAMA: Journal of the American Medical Association; February 1923, Vol. 80 Issue: 5 p303-303, 1p
Abstrakt: The acute anaphylactic shock in dogs is characterized by a sudden pronounced fall in arterial blood pressure. This fall usually begins about forty seconds after the beginning of the intravenous protein injection. The pressure usually reaches a minimum of about 25 mm. of mercury by the end of ninety seconds. In shocks of moderate severity, the pressure remains at this low level for about twenty minutes, and then gradually increases, reaching normal in from one to two hours, depending on the severity of the reaction. With highly sensitized dogs, injected with relatively large doses of the specific foreign protein, little or no recovery takes place, the pressure remaining at a low level till the death of the animal, which usually occurs in about forty minutes.This characteristic fall in arterial blood pressure does not take place in dehepatized (Eck-fistula) dogs. This is true, not only for the mildly sensitized dogs
Databáze: Supplemental Index