| Autor: |
Spies, Tom D., Stone, Robert E., López, Guillermo Garcia, Tellechea, Carlos M. Diaz, Toca, Rubén López, Reboredo, Alfredo, Suárez, Ramón M. |
| Zdroj: |
JAMA: Journal of the American Medical Association; October 1955, Vol. 159 Issue: 7 p645-652, 8p |
| Abstrakt: |
The discovery of each new therapeutic agent is a challenge to the medical profession. When the judicious use of these agents may mean the difference between a useful life and a useless life and between a long life and an early death, the responsibility on the physician is overwhelming. Prednisone and prednisolone are two such agents. They are the chemical analogues of cortisone and hydrocortisone, respectively, and the chemical relations are shown in figure 1. Prednisone was formerly known as metacortandracin and prednisolone as metacortandralone. When given systemically in sufficient amounts, they have the same antirheumatic, anti-inflammatory, and antiallergic effectiveness as pituitary corticotropin (ACTH), cortisone, and hydrocortisone. As can be seen in figure 2, freedom from sodium retention is impressive. Also note in figure 2 that, following the use of cortisone, sodium excretion decreased and body weight tended to increase. The tendency to retain sodium is extremely variable from person |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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