| Abstrakt: |
During the last five years several drugs have been introduced for the treatment of hypertension. Of these, hexamethonium, pentolinium tartrate (Ansolysen), and Ecolid [4, 5, 6, 7-tetrachloro-2-(2-dimethylaminoethyl) isoindoline dimethochloride], which was known experimentally as Su 3088, are orally active agents that reduce blood pressure by blocking or suppressing cholinergic nerve transmission through the sympathetic and parasympathetic ganglions. Hydralazine (Apresoline) hydrochloride has a moderate adrenolytic or sympatholytic action. There is some evidence that it increases renal blood flow, depresses the midbrain, or neutralizes certain humoral vasopressor substances. Alkavervir (Veriloid) and protoveratrines A and B (Veralba), alkaloids of Veratrum viride and Veratrum album, respectively, induce dilatation of arterioles by acting on vasomotor centers or influencing the receptors of the buffer nerves. The Veratrum drugs slow the heart rate and in larger doses cause nausea and then vomiting and salivation. Rauwolfia serpentina, its purified fraction, alseroxylon, or its crystalline alkaloid, reserpine, have a |
