| Abstrakt: |
The major toxic manifestations accompanying prolonged streptomycin therapy are well known. Renal damage, vestibular dysfunction, dermatitis, and other sensitivity reactions have all been observed. The reported incidence of blood dyscrasias, however, has been very low. The initial report of the Streptomycin Committee of the Veterans Administration and offices of the Surgeons General of the Army and Navy,1 stated that of 800 patients treated with streptomycin, in five (0.7%) relatively mild leukopenia with neutropenia developed. One case of agranulocytosis occurred in a patient with miliary tuberculosis. These reactions were felt to be quite definitely caused by streptomycin in the sense that they were alleviated by its withdrawal. Deyke and Wallace2 reccently reported two cases of aplastic anemia, one of which terminated fatally, during streptomycin therapy of 400 patients with tuberculosis at Fitzsimons General Hospital. Autopsy of the fatal case revealed pronounced hypoplasia of the bone marrow. In reviewing the |
