| Abstrakt: |
Keefer and associates1 in their classic paper on the use of penicillin pointed out that urticaria developed in 3.5 per cent of the patients treated with the antibiotic. Hypersensitivity to penicillin, particularly to the commonly used benzylpenicillin, which is known as penicillin G, has been studied by many authors. During the last years Feldman,2 Waldo and Tyson,3 Tunis,4 Cross,5 Andrini,6 Peruccio,7 and Taillens8 published reviews on this subject, while the earlier experimental work of McClosky and Smith9 and Chou and Cutting10 was confirmed by Spada.11 The clinical manifestations of hypersensitivity to penicillin G in man present themselves most frequently as papular or vesicular skin eruptions, urticaria and edema in various localities. Syndromes resembling serum sickness, contact dermatitis and the Arthus type reaction are often observed. Animal experiments12 indicate that penicillin G is a sensitizing agent acting like a hapten |
