| Autor: |
NICHOLS, FENWICK T., WILLIAMS, CAROLINE J. |
| Zdroj: |
JAMA: Journal of the American Medical Association; August 1949, Vol. 140 Issue: 17 p1322-1324, 3p |
| Abstrakt: |
Paroxysmal cold hemoglobinuria is a syndrome characterized by the intravascular hemolysis of red blood cells and the excretion of hemoglobin in the urine following exposure to cold. It is one of the rarer complications of late syphilis. Less than 300 cases were found in the literature1 up to 1932, and since that time only 40 additional cases have been reported.2 In most instances this condition occurs in patients with latent syphilis, either congenital or acquired.In this syndrome the intravascular hemolytic reaction is dependent on the presence in the serum or plasma of a hemolysin, which is absorbed by the red blood cells only at low temperatures. Complement is not necessary for this phase but is essential for hemolysis to occur when the body is rewarmed (the DonathLandsteiner reaction). The serum of patients with paroxysmal cold hemoglobinuria will hemolyze the red blood cells of other persons in the |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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