| Autor: |
ALLEN, J. GARROTT, GROSSMAN, BURTON J., ELGHAMMER, RICHARD M., MOULDER, PETER V., McKEEN, CHARLES L., JACOBSON, LEON O., PIERCE, MILA, SMITH, TAYLOR R., CROSBIE, JAMES M. |
| Zdroj: |
JAMA: Journal of the American Medical Association; April 1949, Vol. 139 Issue: 18 p1251-1254, 4p |
| Abstrakt: |
Hemorrhage arising from abnormal hemostasis is often complicated in origin and troublesome to treat. Bleeding may occur from a single disturbance in the plasma clotting mechanism, in the platelet quantity or in the integrity of the vascular wall. More frequently, spontaneous bleeding is associated with several disorders in one or more of these systems.Reported herein are summarized data on a series of patients with spontaneous bleeding who had a similar clotting abnormality. This clotting defect was characterized by an increase in the protamine titration1 and was frequently associated with a prolongation in the whole blood clotting time.2 Many of these patients also had thrombopenia of moderate or severe degree.The nature of the defect revealed by the protamine titration resembles, but is not identical with, that produced by the intravenous injection of commercial beef heparin.2 Moreover, the protamine titration may be influenced by factors other than |
| Databáze: |
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