STREPTOMYCIN IN TUBERCULOUS MENINGITIS

Autor: MEHAS, C. P., TRUAX, WAYNE E.
Zdroj: JAMA: Journal of the American Medical Association; September 1947, Vol. 135 Issue: 3 p155-157, 3p
Abstrakt: Tuberculous meningitis has always carried a hopeless prognosis. The use of streptomycin in the treatment of this disease has already altered the outlook. Waksman and his associates1 reported the isolation of a new antibiotic agent in 1944. Feldman and Hinshaw reported in 19442 its apparent ability to suppress the growth of Mycobacterium tuberculosis in guinea pigs. Since that time several reports in the literature have confirmed the bacteriostatic action of streptomycin on Myco. tuberculosis. Its first successful use in tuberculous meningitis was reported by Cooke, Dumphy and Blake,3 who treated an infant 1 year of age. Krafchik4 reported another apparent arrest in a child 5 months of age, significant in that no residual neural damage was noted. Recently Hinshaw, Feldman and Pfeutze5 reported a series of 9 cases of combined miliary and meningeal tuberculosis in 4 of which the patients survived. In all their successful
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