| Autor: |
BULLOWA, JESSE G. M., ALTERMAN, JANET, KATONA, NICHOLAS, SCANNELL, MARGARET, ROBINSON, ARTHUR |
| Zdroj: |
JAMA: Journal of the American Medical Association; November 1942, Vol. 120 Issue: 12 p886-890, 5p |
| Abstrakt: |
We have undertaken a clinical and immunologic study involving the antitoxin immunity actively induced and passively conferred in well and in ill children, based on the fact recently demonstrated by Merritt Roberts1 that endotoxin and exotoxin of Hemophilus pertussis are identical and on the fact previously demonstrated that this toxin is antigenic. Bordet and Gengou2 extracted a toxic substance from H. pertussis by grinding the organisms. They did not demonstrate its antigenicity and termed it endotoxin. Other investigators, notably Tessier and his co-workers,3 Lawson4 and Roberts,1 demonstrated that such extracts were antigenic. Subsequently washings from whole organisms and broth mediums in which the organisms had grown were found by Evans5 and Mishulow6 to be toxic and to produce antitoxins. Mishulow and later Koplik7 demonstrated, by the Shwartzman phenomenon, a toxin in some cultures of H. pertussis. Sprunt8 produced identical pneumonic lesions |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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