Autor: |
LONG, PERRIN H., HAVILAND, JAMES W., EDWARDS, LYDIA B., BLISS, ELEANOR A. |
Zdroj: |
JAMA: Journal of the American Medical Association; August 1940, Vol. 115 Issue: 5 p364-368, 5p |
Abstrakt: |
It has become increasingly evident as time goes on that physicians often hesitate to use sulfanilamide or its derivatives because of a fear of the toxic manifestations of these drugs, while patients, because of their lack of appreciation of the possible toxic manifestations of this group of drugs, demand that the drugs be administered to them. These attitudes have at times brought about a somewhat peculiar situation.It has seemed to us that physicians have been "oversold" on the dangers connected with the use of sulfanilamide and its derivatives and that these drugs can be used with greater impunity than has hitherto been considered possible. It is for this reason that we have carefully analyzed the incidence and types of toxic reactions occurring in hospitalized adults, 1,000 of whom were treated with sulfanilamide, 297 with sulfapyridine and 291 with sulfathiazole in the Johns Hopkins Hospital during the past few years. |
Databáze: |
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