| Autor: |
Wendt, Vernon E., Puro, Henry E., Shapiro, Jack, Mathews, William, Wolf, Paul L. |
| Zdroj: |
JAMA: Journal of the American Medical Association; May 1964, Vol. 188 Issue: 8 p755-757, 3p |
| Abstrakt: |
MAO is one of the enzymes involved in the metabolism of potent biogenic amines such as l-epinephrine, l-norepinephrine, serotonin, tyramine, and dopamine.4 After the administration of MAO inhibitors, it is believed that there is an increase in tissue levels of l-epinephrine and l-norepinephrine. Tyramine may act as a pressor substance normally degraded by MAO, or it may provoke the release of stored catechol amines.5 As contrasted with pheochromocytoma, urinary 3-methoxy, 4-hydroxymandelic acid determinations have been reported as normal in those cases of cheese-induced hypertension so studied. Perhaps metanephrine or normetanephrine output must be measured in this situation, as the 3-methoxy, 4-hydroxymandelic acid pathway is dependent on MAO activity.Pargyline hydrochloride (N-benzyl-N-methyl-2-propynylamine hydrochloride) is a nonhydrazine MAO inhibitor seven to ten times as potent as iproniazid, with an effect lasting up to ten days after administration of a single oral dose. This drug was evaluated as an antihypertensive agent |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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