| Abstrakt: |
THE TREATMENT OF EDEMA occurring with such diseases as heart failure, cirrhosis of the liver, and chronic nephritis has always been a challenge. The problems associated with edema of renal origin have been particularly troublesome. Fortunately, in cases of chronic nephritis, a number of approaches have been available. Restriction of salt, the use of steroids, and administration of various diuretics such as chlorothiazide and meralluride sodium have been quite effective. However, a point is eventually reached in therapy at which the patient becomes resistant to all approaches. Thus, the advent of a new agent for use in these conditions is always of great interest.In recent years, it has been pointed out that there is an increased secretion of aldosterone in patients who have the nephrotic syndrome. Since aldosterone is known to act on the renal tubules to increase the reabsorption of sodium, any increase in dosage of the hormone |
