Hydroxocobalamin: III. Long-Acting Effects of Massive Parenteral Doses on Vitamin B12 Blood Levels in Man

Autor: Glass, George B. Jerzy, Lee, Duk Ho, Skeggs, Helen R., Stanley, Josephine L.
Zdroj: JAMA: Journal of the American Medical Association; February 1963, Vol. 183 Issue: 6 p425-429, 5p
Abstrakt: To explore the long-range effects of hydroxocobalamin (Alpharedisol) injections upon B12 blood levels, the authors compared the effects of 10 to 14 weekly intramuscular injections of hydroxocobalamin and cyanocobalamin in 50 persons. During the cyanocobalamin treatment, B12. blood levels remained in the range of 1,000 to 1,700 μμg/ml (the maximal value not exceeding 2,000 μμg/ml), but during hydroxocobalamin therapy they leveled off at an average of 8,000 μμg/ml, with the maximal values reaching as high as 15,000 μμg/ml. After discontinuation of the cyanocobalamin treatment, B12 blood levels reverted to normal within four to five weeks, but after hydroxocobalamin they did not return to the upper limit of the norm for six to seven months. At the end of the year, they were still about three times higher than before the treatment.
Databáze: Supplemental Index