| Abstrakt: |
SOME THEORETICAL and practical objections have been raised concerning the use of the Quick one-stage determination of prothrombin complex activity for the laboratory control of anticoagulant therapy with prothrombinopenic drugs. Several more complex tests of the clotting mechanism have been suggested to replace it, but in our laboratory these were not found to be superior to the Quick procedure. One of the important theoretical objections to the Quick technique and its modifications is that, because a potent tissue thromboplastin is added to the test plasma in the performance of the tests, they are completely insensitive to deficits of clotting factors which act in the first stage of clot formation, the generation of plasma thromboplastin. Since coumarin and indanedione derivatives depress the hepatic synthesis of Factor IX (plasma thromboplastin component, Christmas Factor) and Factor X ( Stuart-Prower ), both of which function in the generation of plasma thromboplastin, it would be |
